Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture

Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture

BACKGROUND This paper considers a real-world optimization problem involving the identification of cost-effective equipment sizing strategies for the sequence of chromatography steps employed to purify biopharmaceuticals. Tackling this problem requires solving a combinatorial optimization problem subject to multiple constraints, uncertain parameters, and time-consuming fitness evaluations. RES...

Mechanical characterisation of agarose-based chromatography resins for biopharmaceutical manufacture.

Mechanical characterisation of agarose-based resins is an important factor in ensuring robust chromatographic performance in the manufacture of biopharmaceuticals. Pressure-flow profiles are most commonly used to characterise these properties. There are a number of drawbacks with this method, including the potential need for several re-packs to achieve the desired packing quality, the impact of...

Production Planning of Biopharmaceutical Manufacture

Multiproduct manufacturing facilities running on a campaign basis are increasingly becoming the norm for biopharmaceuticals, owing to high risks of clinical failure, regulatory pressures and the increasing number of therapeutics in clinical evaluation. The need for such flexible plants and cost-effective manufacture pose significant challenges for planning and scheduling, which are compounded b...

Fuzzy Mathematical Model For A Lot-Sizing Problem In Closed-Loop Supply Chain

The aim of lot sizing problems is to determine the periods where production takes place and the quantities to be produced in order to satisfy the customer demand while minimizing the total cost. Due to its importance on the efficiency of the production and inventory systems, Lot sizing problems are one of the most challenging production planning problems and have been studied for many years wit...

Optimization of manufacture and examination of micropellets based on pharmaceutical technological and biopharmaceutical parameters